Efficacy and safety of non-ablative vs. ablative lasers for acne scarring: A meta-analysis

Acne scarring significantly affects physical appearance and psychological well-being, prompting the exploration of various treatment options, including ablative and non-ablative laser therapies. The debate around their efficacy and safety persists, underscoring the need for a comprehensive analysis. This meta-analysis compares the therapeutic outcomes and safety profiles of ablative and non-ablative laser treatments for acne scars, based on a comprehensive review of clinical trials conducted up to March 2023. The evaluation focused on clinical improvement, patient satisfaction, and the incidence of treatment-related complications. Analysis of seven studies encompassing 186 cases revealed that non-ablative lasers are more effective for atrophic acne scars, offering a better safety profile with fewer adverse effects, such as reduced pain and shorter erythema durations. Conversely, ablative laser therapy demonstrated superior results in both observer-based and patient-driven evaluations. The findings suggest that while both laser types are effective in mitigating acne scarring, the choice between ablative and non-ablative lasers should consider the balance between efficacy and safety. The study highlights the necessity for more standardized research to refine laser treatment protocols for acne scars, aiming to optimize outcomes and minimize risks.