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Sensitive Multichannel 19F Magnetic Resonance Imaging Enabled by Paramagnetic Fluorinated Ionic Liquid-Based Probes.

Limin Chen1, Yuhang Jiang1, Nan Xiong1

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

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|March 11, 2025
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Summary

This study enhances fluorine-19 magnetic resonance imaging (MRI) probes by using manganese ions to improve fluorinated ionic liquids (FILs). This method boosts imaging performance for clearer in vivo results.

Keywords:
fluorinated ionic liquidsliposilmultichannel 19F MRIparamagnetic relaxation enhancementrelaxation modulation

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Area of Science:

  • Biomedical Imaging
  • Materials Science
  • Radiochemistry

Background:

  • Fluorine-19 magnetic resonance imaging (MRI) offers advantages over proton MRI due to its low biological background and high sensitivity.
  • Fluorinated ionic liquids (FILs) are promising 19F sources for MRI probes due to solubility and high fluorine content.
  • The effectiveness of FIL-based probes is limited by suboptimal 19F relaxation times (T1 and T2).

Purpose of the Study:

  • To develop a strategy for modulating 19F relaxation times in FILs to enhance their MRI imaging capacity.
  • To create high-performance 19F MRI probes using FILs and paramagnetic Mn2+ ions.
  • To demonstrate the feasibility of using relaxation modulation for advanced 19F MRI applications.

Main Methods:

  • Exploited the paramagnetic relaxation enhancement effect of Mn2+ ions to tune the T1 and T2 relaxation times of three FILs (EMIMBF4, BMIMOTf, BMIMPF6).
  • Optimized Mn2+ concentrations to achieve significant signal enhancement.
  • Encapsulated FILs and Mn2+ ions within liposils to create stable 19F MRI probes for in vivo studies.

Main Results:

  • Achieved over 5-fold signal enhancement in FILs by modulating 19F relaxation times with Mn2+ ions.
  • Constructed liposil-encapsulated FIL-Mn2+ probes enabling fast and clear in vivo 19F MRI.
  • Validated the capacity for multiplexed 19F MRI using a probe containing multiple FILs and Mn2+.

Conclusions:

  • Paramagnetic FIL-based probes show significant potential for in vivo "hot spot" 19F MRI.
  • Relaxation time modulation is a feasible and effective strategy for developing high-performance 19F MRI probes.
  • This approach advances the application of 19F MRI in biomedical research and clinical diagnostics.