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Related Experiment Video

Updated: May 23, 2025

Long-term Time Lapse Imaging of Mouse Cochlear Explants
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Expression of S100β during mouse cochlear development.

Wenjing Liu1, Yongchun Zhang2, Cheng Liang2

  • 1Otolaryngology & Head and Neck Center, Cancer Center, Department of Otolaryngology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou.

European Journal of Histochemistry : EJH
|March 11, 2025
PubMed
Summary
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S100β protein expression changes dynamically in the developing mouse cochlea, appearing in key auditory structures like the organ of Corti and stria vascularis, suggesting a role in hearing development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Auditory Science

Background:

  • The S100 calcium-binding protein family plays diverse roles in cellular functions.
  • Understanding the spatiotemporal expression of S100β is crucial for elucidating its function in the auditory system.

Purpose of the Study:

  • To investigate the expression pattern of S100β in the mouse cochlea during development.
  • To explore the potential role of S100β in auditory system development and function.

Main Methods:

  • Immunofluorescence was used to detect S100β expression in mouse cochlear tissues.
  • Analysis spanned from embryonic day 17 (E17) to postnatal day 32 (P32).

Main Results:

  • S100β expression was initially detected at E18.5 in the organ of Corti and stria vascularis.

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  • Expression was observed in pillar cells and Deiter's cells of the organ of Corti, and in the spiral ligament and spiral limbus.
  • Expression patterns changed dynamically, with S100β declining in some cell types in adulthood.

    • Conclusions:

    • Dynamic spatiotemporal expression of S100β suggests its involvement in cochlear development.
    • S100β may play a significant role in the formation and function of the auditory system.