Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 23, 2025

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization.

Dong Eun Kim¹, Do Young Park², Jong Chul Han^1,2

¹Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Korea.

Translational Vision Science & Technology

|March 11, 2025

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Massive Suprachoroidal Hemorrhage Following Needling Bleb Revision: Two Case Reports.

Korean journal of ophthalmology : KJO·2026

Same author

Zonally patterned demineralized bone matrix-meniscus ECM composite scaffold directing region-specific fibrochondrogenic and angiogenic responses.

Regenerative biomaterials·2026

Same author

Long-Term Results of Medial Fixed-Bearing Unicompartmental Knee Arthroplasty with Miller-Galante Prosthesis: A Minimum 10-Year Follow-Up Study.

Medicina (Kaunas, Lithuania)·2026

Same author

A-stream glaucoma shunt versus trabeculectomy: 1-year results on efficacy and safety.

Scientific reports·2026

Same author

Optimizing Cell Isolation for Adipose- and Synovium Derived Mesenchymal Stem Cells from Infrapatellar Fat Pad.

Tissue engineering and regenerative medicine·2026

Same author

Efficacy of an intravenous acetaminophen/ibuprofen fixed-dose combination after total knee arthroplasty.

BMC musculoskeletal disorders·2026

Aqueous humor viscosity significantly increased in corneal neovascularization (CNV) models, correlating with elevated vascular endothelial growth factor-A (VEGF-A). This suggests viscosity may predict outcomes in conditions like neovascular glaucoma.

Area of Science:

Ophthalmology
Biochemistry
Neovascularization Research

Background:

Corneal neovascularization (CNV) involves the growth of new blood vessels in the cornea.
Vascular Endothelial Growth Factor-A (VEGF-A) is a key mediator in angiogenesis.
Aqueous humor (AH) properties may reflect ocular conditions.

Purpose of the Study:

To investigate the relationship between aqueous humor (AH) viscosity and vascular endothelial growth factor-A (VEGF-A) in a corneal neovascularization (CNV) model.
To determine if AH viscosity can serve as a biomarker in ocular diseases.

Main Methods:

Corneal neovascularization (CNV) was induced in rabbits using alkaline burns.
Aqueous humor (AH) was collected from induced and control eyes.
VEGF-A concentration was measured by ELISA, and AH viscosity was determined using a viscometer.

More Related Videos

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Related Experiment Videos

Last Updated: May 23, 2025

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Main Results:

VEGF-A concentration and total protein concentration were significantly elevated in CNV-induced eyes compared to controls (P < 0.01).
Aqueous humor (AH) viscosity was significantly increased in CNV-induced eyes (P < 0.01).
AH viscosity showed a strong positive correlation with VEGF-A concentration in CNV-induced eyes (r = 1.00, P = 0.02).

Conclusions:

Aqueous humor (AH) viscosity is elevated in corneal neovascularization (CNV) and strongly correlates with VEGF-A levels.
AH viscosity may serve as a potential biomarker for predicting intraocular pressure (IOP) or surgical outcomes in conditions such as neovascular glaucoma.