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Family History in the Context of CKD
Francesca Zanoni1,2, Maddalena Marasa2, Lucrezia Carlassara2
1Department of Nephrology, Dialysis, and Kidney Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Journal of the American Society of Nephrology : JASN
|March 11, 2025
Insights
Family history of conditions like diabetes increases comorbidity risk in Chronic Kidney Disease (CKD) patients. Family history of diabetes, not CKD, independently predicts CKD progression.
Area of Science:
- Nephrology
- Genetics
- Epidemiology
Background:
- Family history may indicate shared genetic/environmental risks for diseases.
- The impact of family history on Chronic Kidney Disease (CKD) patient outcomes is not fully understood.
- Investigating family history's role in CKD comorbidities and progression is crucial.
Purpose of the Study:
- To examine associations between family history of CKD, diabetes, and other conditions with comorbidities in CKD patients.
- To determine if family history influences kidney disease progression in individuals with CKD.
Main Methods:
- Observational study of two prospective CKD cohorts (Cure Glomerulopathy Network and Chronic Renal Insufficiency Cohort).
- Included 2573 adults and children and 3939 adult participants.
- Self-reported first-degree family history data analyzed for associations with comorbidities and CKD progression using multivariable models.
Main Results:
- Family history of diabetes, cancer, and cardiovascular disease correlated with higher risks of these conditions in CKD patients.
- Family history of diabetes independently predicted CKD progression, irrespective of diabetes status or polygenic risk score (PRS) for diabetes.
- While CKD PRS predicted progression, family history of CKD did not independently predict progression in existing CKD patients.
Conclusions:
- Collecting family history data enhances clinical risk stratification for CKD patients.
- Family history of diabetes is a significant, independent predictor of CKD progression.
- Family history provides valuable insights into CKD risk and progression beyond genetic predisposition alone.
Abstract
No abstract available in PubMed .
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