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The sex-specific difference in age-related aortic regional morphological changes
Zixuan Meng1, Lele Cheng2, Wenjun Liu1
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Aging Clinical and Experimental Research
|March 11, 2025
Summary
Females experience more rapid age-related aortic changes, including increased diameter and tortuosity, compared to males. These sex-specific differences in aortic aging highlight the need for tailored preventive strategies.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Gerontology
Background:
- Aging affects aortic morphology, but sex-specific differences are not fully understood.
- Computed tomography (CT) imaging provides detailed insights into aortic structure.
Purpose of the Study:
- To investigate sex-based variations in age-related aortic morphological changes.
- To compare body surface area (BSA)-adjusted aortic diameters and tortuosity between sexes across different age groups.
Main Methods:
- Retrospective analysis of contrast-enhanced chest and abdominal CT scans from 208 participants.
- Stratification into age groups and sex-specific comparisons of BSA-adjusted aortic diameters and tortuosity.
- Validation using previously published data on arterial stiffness (brachial-pulse wave velocity - baPWV).
Main Results:
- Females showed a more rapid age-related increase in BSA-adjusted aortic diameters than males.
- Females exhibited significantly greater BSA-adjusted aortic tortuosity in all segments after age 40.
- Accelerated age-related increases in aortic tortuosity and baPWV were observed in females.
Conclusions:
- Significant sex-based variations exist in the rate of aortic morphological aging.
- Females demonstrate more pronounced age-related changes in aortic tortuosity and stiffness.
- Tailored preventive measures for females are recommended due to observed sex-specific disparities in aortic aging.
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