Multifunctional metal complex systems emerging from analytical chemistry for theranostic applications
1Graduate School of Environmental Studies, Tohoku University, 6-6-07 Aramaki-Aoba, Aoba-ku, Sendai, 980-8579, Japan. iki@tohoku.ac.jp.
Summary
Metal complexes are key in analytical chemistry for ion detection and separation. Integrating them with materials enhances their analytical and theranostic applications through supramolecular interactions.
Area of Science:
- Analytical Chemistry
- Materials Science
- Supramolecular Chemistry
Background:
- Metal complexes are crucial in analytical chemistry for ion detection and separation.
- Non-covalent integration of metal complexes with various media enhances their functionality.
- The author has extensively studied diverse metal complex systems over four decades.
Purpose of the Study:
- To review the development and applications of multifunctional metal complex systems.
- To highlight the role of synergistic and supramolecular interactions in their design.
- To showcase applications ranging from analytical sensing to theranostics.
Main Methods:
- Exploration of thiacalixarene-lanthanide(III) complexes, diradical platinum(II) complexes, and MOF-74.
- Integration of metal complexes with separation platforms and materials.
- Utilizing non-covalent interactions to achieve multifunctional properties.
Main Results:
- Demonstrated luminescent supramolecular sensors for soft-metal ions.
- Developed upconverting complexes and near-infrared probes for pH and hydrophobic cavities.
- Showcased applications in magnetic resonance imaging, photoacoustic imaging, and various therapies.
Conclusions:
- Multifunctionality arises from cooperative, synergistic, and supramolecular nature driven by non-covalent interactions.
- Analytical chemistry is fundamental to the discovery and development of these advanced systems.
- Metal complex systems offer versatile solutions for both analytical challenges and theranostic applications.
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