Detection of Monocytic Myeloid-Derived Suppressor Cells in the Human Brain and Blood
María Cristina Ortega1,2, Virginia Vila-Del Sol3, Isabel Machín-Díaz1,2
1Neuroimmune-Repair Group, Hospital Nacional de Parapléjicos-SESCAM-IDISCAM, Toledo, Spain.
Abstract:
The analysis of monocytic myeloid-derived suppressor cells (M-MDSCs) is gaining importance in the complex pathological context of neuroinflammatory diseases. M-MDSCs exert their potent immunoregulatory activity in both the central nervous system and the periphery. Since M-MDSCs lack a specific marker for their identification, the design and development of complex antibody panels for advanced confocal microscopy and flow cytometry techniques are needed to consistently and systematically detect them in both the brain and peripheral blood of human subjects.
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