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Updated: May 23, 2025

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Published on: June 13, 2022
Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin
Xian-Hui Zhao1, Liang Zhao1, Yue-Cheng Wu1
1Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai, P. R. China.
Abstract:
The formal divergent synthesis of natural products (-)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (-)-warburganal, while oxidation of I to III via allylic oxidation and in situ hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.
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