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Interactions Between Commensal Microbes and Mosquito-Borne Viruses
Yibin Zhu1,2,3, Yingyi Cao1, Liping Jiang4
1New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing, China;
Annual Review of Virology
|March 11, 2025
Summary
Microbes in hosts and mosquitoes significantly impact mosquito-borne virus spread. Understanding these interactions may lead to new ways to control viral diseases.
Area of Science:
- Microbiology
- Virology
- Public Health
Background:
- Mosquito-borne viruses present a growing global health challenge.
- Current preventive and therapeutic options are limited.
- Understanding virus-host-vector interactions is crucial for developing new strategies.
Purpose of the Study:
- To review the complex interplay between commensal microbes and mosquito-borne viruses.
- To explore how host and mosquito microbiota influence viral pathogenesis and transmission.
- To discuss microbe-based interventions for disease control.
Main Methods:
- Literature review and synthesis of existing research on host-microbe-virus interactions.
- Analysis of the role of gut and skin microbiota in viral infection and vector competence.
- Examination of symbiotic microbes within mosquitoes and their impact on viral transmission.
Main Results:
- Host gut microbiota affects viral pathogenesis.
- Host skin microbiota influences mosquito attraction and virus transmission.
- Mosquito symbiotic microbes regulate viral transmission via immune modulation and effector molecules.
Conclusions:
- Commensal microbes play a critical role in mosquito-borne viral disease dynamics.
- Targeting these microbial interactions offers a promising avenue for novel interventions.
- Further research into microbe-based strategies could lead to effective disease suppression.
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