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Label-Free Dual-Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury.

Shensheng Zhao^1,2,3, Xingxing Zhang^2,3, Keith Bailey⁴

¹Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|March 11, 2025

Summary

This summary is machine-generated.

This study introduces a novel 3D imaging technique to monitor kidney microcirculation changes in acute kidney injury (AKI). The advanced method reveals significant reductions in vascular density and oxygenation, aiding early diagnosis.

Keywords:

acute kidney injury label‐free imaging microvessel imaging photoacoustic imaging super‐resolution ultrasound imaging

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Area of Science:

Biomedical Engineering
Medical Imaging
Nephrology

Background:

Acute kidney injury (AKI) is linked to renal microcirculation disruptions.
Current non-invasive monitoring tools for renal microcirculation are limited, hindering early AKI diagnosis.

Purpose of the Study:

To develop and validate a label-free 3D multi-parametric imaging technique for quantitative assessment of renal microcirculation.
To investigate structural and functional changes in renal vasculature, hemodynamics, and oxygenation in an AKI model.

Main Methods:

A novel imaging system combining photoacoustic and super-resolution ultrasound was developed.
The system achieves 26 µm resolution for visualizing the entire renal vasculature.
The technique was applied to an established AKI model for quantitative analysis.

Main Results:

Demonstrated a 54% reduction in vascular density in the AKI model.
Observed a 14.1% decrease in renal oxygenation and a 61% decline in relative blood volume (rBV) 3 days post-surgery.
Findings were corroborated by blood tests and histopathological analysis.

Conclusions:

The developed 3D renal imaging technique provides high-resolution, multi-parametric insights into renal microcirculation.
This method shows significant potential for advancing the understanding of renal physiology and early detection of renal injury.
The technique offers a valuable tool for investigating kidney disease progression and therapeutic responses.