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Updated: Jun 15, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

[Neurolymphomatosis].

Fanny Urbain¹, Louise Bicart-See², Clovis Adam³

¹Service de médecine interne et immunologie clinique, hôpital Bicêtre, faculté de médecine Paris Saclay, Assistance publique-Hôpitaux de Paris, université Paris Saclay, 94275 Le Kremlin-Bicêtre cedex, France.

La Revue De Medecine Interne

|March 11, 2025

Summary

This summary is machine-generated.

Neurolymphomatoses (NL), direct infiltration of the peripheral nervous system (PNS) by cancer cells, present diagnostic challenges. Early consideration in painful neuropathies and resistance to treatment is key for timely diagnosis and management.

Keywords:

Lymphoma Lymphome Neurolymphomatose Neurolymphomatosis Peripheral nervous system Système nerveux périphérique

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Area of Science:

Neurology
Oncology
Pathology

Context:

Neurolymphomatoses (NL) involve direct infiltration of the peripheral nervous system (PNS) by lymphomatous or leukaemic cells.
Diagnosis is challenging, often requiring invasive peripheral nerve histology.
Consider NL in painful neuropathies resistant to standard treatments.

Purpose:

To define neurolymphomatoses (NL) and their diagnostic considerations.
To classify primary and secondary NL.
To highlight the need for further research into genesis and treatment.

Summary:

NL are rare conditions involving lymphoma or leukemia cells infiltrating the PNS.
Common histological types include diffuse large B-cell lymphoma.
Primary NL are confined to the PNS, while secondary NL indicate systemic disease.

Impact:

Emphasizes the need for considering NL in specific clinical scenarios.
Highlights limitations of current diagnostic methods.
Underscores the necessity for multicenter studies to advance diagnostic and therapeutic strategies for neurolymphomatoses.