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Articles linked to this work by shared authors, journal, and citation graph.

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Isolated Meniscus Repairs in Youth Have a 19% Complication Rate and 9% Failure Rate With Variations by Tear Type, Location, Range of Motion Protocol, and Sex at 8 Months.

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Related Experiment Video

Updated: May 23, 2025

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
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Generating New Meniscus Therapies via Recent Breakthroughs in Development, Model Systems, and Clinical Diagnostics.

Rebecca M Irwin1,2, Matthew Brown3, Matthew F Koff4

  • 1Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|March 11, 2025
PubMed
Summary

Recent advances in meniscus research offer new strategies for tissue repair and preventing osteoarthritis after surgery. This review highlights key findings in development, animal models, and clinical interventions to improve patient outcomes.

Keywords:
imagingmaturationmechanicsregenerationrepairsequencing

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Area of Science:

  • Biomedical Engineering
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Meniscal injuries are common, leading to osteoarthritis (OA) even after surgical repair.
  • There is a critical need for improved meniscal repair to restore function and prevent joint degeneration.

Purpose of the Study:

  • To review recent (2020-2024) advances in meniscus research across basic science, translational, and clinical studies.
  • To highlight new strategies for meniscus repair and OA prevention.

Main Methods:

  • Review of recent scientific literature (2020-2024).
  • Analysis of studies on meniscus development, animal models, finite element models, and clinical interventions.
  • Examination of structure-function relationships across multiple length scales.

Main Results:

  • Identification of key progenitor cells and vascularity changes in meniscus development, aging, and degeneration.
  • Advancements in animal and finite element models enhance understanding of meniscus function and preclinical therapy evaluation.
  • Progress in machine learning diagnostics and surgical techniques improves evidence-based clinical practices.

Conclusions:

  • Recent research provides insights into meniscus biology and pathology, informing novel repair strategies.
  • Improved models and clinical tools are advancing meniscus research and patient care.
  • Translating basic science discoveries into effective clinical treatments remains a key challenge.