Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lightweight English Text Classification with Deep Learning Based on Complex System Theory.

Journal of visualized experiments : JoVE·2026

Same author

Inhibitory effect and mechanism of Nb<sub>2</sub>C nanochaperone on bovine serum albumin unfolding.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Same author

Prediagnosis frailty and survival after cancer in middle-aged and older adults: a population-based cohort study.

Aging clinical and experimental research·2026

Same author

Comparison of the diagnostic power of serum circulating miR-21, VEGF, and CA15-3 in breast cancer.

Frontiers in oncology·2026

Same author

Shaping my own future: a latent profile analysis of how career resources influence future work self-salience among Chinese vocational students.

BMC psychology·2026

Same author

Trait-mediated, size-dependent retention of particulate matter by urban roadside vegetation.

Ecotoxicology and environmental safety·2026

Search research articles

Related Experiment Video

Updated: May 23, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Complementary classification of hypertrophic cardiomyopathy using unsupervised cluster analysis on left ventricular

Dandan Sun^1,2, Xingyu Fang^1,2, Yuzhu Zhang^1,2

¹Department of Ultrasound, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, 110067, China.

Scientific Reports

|March 12, 2025

Summary

This summary is machine-generated.

Researchers identified two hypertrophic cardiomyopathy (HCM) subtypes based on left ventricular function. Subtype 1 HCM patients showed impaired function and higher atrial fibrillation risk, aiding personalized treatment for hypertrophic cardiomyopathy.

Keywords:

Atrial fibrillation Cluster analysis Hypertrophic cardiomyopathy Multi-dimensional echocardiographic parameters

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Related Experiment Videos

Last Updated: May 23, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Area of Science:

Cardiology
Biomedical Engineering
Medical Imaging

Background:

Current hypertrophic cardiomyopathy (HCM) classification relies on hypertrophy site and outflow tract obstruction.
A functional classification could improve risk stratification and management for HCM patients.

Purpose of the Study:

To develop a complementary classification for hypertrophic cardiomyopathy (HCM) based on left ventricular (LV) function.
To identify distinct HCM subtypes with varying cardiovascular risks and inform individualized treatment strategies.

Main Methods:

Utilized multi-dimensional echocardiographic parameters (conventional, TDI, STE) in 266 HCM patients and 169 healthy controls.
Employed principal component analysis and unsupervised cluster analysis to define HCM subtypes based on LV function.
Compared clinical variables and evaluated prognosis, specifically atrial fibrillation risk, between identified subtypes.

Main Results:

Two HCM subtypes were identified: Subtype 1 (n=123) and Subtype 2 (n=143).
Both subtypes exhibited impaired LV diastolic and systolic function compared to controls, with greater decline in Subtype 1.
Subtype 1 HCM showed distinct functional characteristics (e.g., increased strain, decreased untwist rate) and a significantly higher risk of atrial fibrillation (HR: 4.34).

Conclusions:

Stratified HCM patients into two functional subtypes with differential diastolic and systolic performance.
Subtype 1 HCM is associated with poorer cardiac function and increased susceptibility to atrial fibrillation.
This functional classification offers a potential tool for targeted management of hypertrophic cardiomyopathy.