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Related Experiment Video

Updated: May 3, 2026

Apparatus for Harvesting Tissue Microcolumns
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Alternative treatment for recurrent keloids: initial clinical experience with Rhenium-188 using a specialized device.

Kgomotso M G Mokoala1,2, Linda Nonjola1,2, Thabiso Moeng1,2

  • 1Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.

European Journal of Nuclear Medicine and Molecular Imaging
|March 12, 2025
PubMed
Summary

Rhenium-188 (Re-188) topical treatment offers a promising alternative for recalcitrant keloids, achieving a 72% complete response rate with a low 7% recurrence. This novel approach provides effective keloid management when other therapies fail.

Keywords:
188ReKeloidsRhenium SCTSingle session therapy

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Area of Science:

  • Dermatology
  • Nuclear Medicine
  • Oncology

Background:

  • Keloids present a significant management challenge due to variable treatment success and high recurrence rates.
  • Established therapies including surgery, intralesional steroids, and radiation often yield suboptimal outcomes.
  • Radioactive isotopes like Holmium-166 and Phosphorus-32 have shown efficacy in superficial skin lesions, paving the way for novel radiotherapeutic approaches.

Purpose of the Study:

  • To evaluate the initial experience and efficacy of Rhenium-188 (Re-188) topicalクリーム (SCT) in treating recurrent keloid lesions.
  • To assess the safety, clinical outcomes, and cosmetic results of Re-188 SCT in patients refractory to conventional treatments.

Main Methods:

  • Recurrent keloid patients, who had failed prior therapies, were treated with Re-188 SCT using a specialized applicator (Oncobeta).
  • A single topical application of a Re-188 jelly matrix was administered, aiming for 30 Gy at a 3 mm depth.
  • Patients underwent follow-up at regular intervals to monitor for side effects and evaluate clinical and cosmetic outcomes.

Main Results:

  • A total of 58 keloid lesions were treated, predominantly in the head and neck region.
  • Complete response was observed in 72% of lesions, with a low recurrence rate of 7% after a median follow-up of 37 months.
  • Hypopigmentation was the most common long-term side effect; the specialized applicator system demonstrated flexibility and reduced morbidity.

Conclusions:

  • Rhenium-188 (Re-188) SCT is a viable and effective alternative for managing keloids resistant to conventional therapies.
  • The specialized applicator system facilitates flexible application, minimizes patient morbidity, and achieves results comparable to existing treatments.
  • This study highlights the potential of Re-188 SCT as a valuable tool in the multidisciplinary approach to keloid management.