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One anti-tumour C21 steroidal glycoside from Cynanchum wallichii Wight
Shuo Liu1, Yong Cui2, Qianxiaochuan Wang3
1Department of Pharmacy, Northeastern University Hospital, 110004, China.
Abstract:
The roots of Cynanchum wallichii Wight is rich in C21 steroidal glycosides according to previous research. In this study, a systematic chemical study was performed on the roots of C. wallichii, leading to the isolation of one previously undescribed C21 steroidal glycoside compound (1) and a known compound, gagamine (2). In vitro bioassay indicated that compound 1 showed a strong inhibitory effect on AGS cells, with the IC50 value 7.8 μM.
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