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lncRNA - Long Non-coding RNAs02:39

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Related Experiment Video

Updated: May 23, 2025

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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The Impact of High lncRNA Expression on Clinicopathological Characteristics and Prognosis of Endometrial Cancer

Xiaotong Zhao1, Ziling Yang1, Tianjiao Zheng1

  • 1Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Cancer Medicine
|March 12, 2025
PubMed
Summary

High expression of long non-coding RNAs (lncRNAs) in endometrial carcinoma (EC) patients is linked to poorer prognosis and advanced disease. These lncRNAs may serve as potential biomarkers and therapeutic targets for EC.

Keywords:
clinicopathological characteristicsendometrial carcinomalong non‐coding RNAmeta‐analysisprognosis

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Area of Science:

  • Oncology
  • Genetics
  • Bioinformatics

Background:

  • Systematic bioinformatics analyses are investigating long non-coding RNA (lncRNA) interactions in endometrial carcinoma (EC) for prognostic prediction.
  • Evidence linking abnormal lncRNA expression to EC pathological characteristics and prognosis remains limited.
  • This meta-analysis systematically evaluates the association between upregulated lncRNA expression and EC patient outcomes.

Purpose of the Study:

  • To evaluate the relationship between upregulated lncRNA expression and clinicopathological features in EC.
  • To assess the association between upregulated lncRNA expression and the five-year survival rate in EC patients.
  • To determine the correlation between upregulated lncRNA expression and progression-free survival (PFS) in EC.

Main Methods:

  • A systematic literature search was conducted across seven databases (CNKI, Wanfang, Wipu, PubMed, Web of Science, Cochrane Library, Embase) until November 27, 2022.
  • Heterogeneity was assessed using Cochran's Q and I² statistics.
  • Statistical analyses were performed using Stata 14.0 software.

Main Results:

  • The meta-analysis included 30 studies with 2469 EC patients, examining 24 upregulated lncRNAs.
  • Higher lncRNA expression correlated with later FIGO stage, poorer histological grade, deeper myometrial invasion, and increased risk of lymphatic, nodal, and distant metastasis (all p < 0.05).
  • Elevated lncRNA expression was significantly associated with reduced five-year survival and PFS (p < 0.05).

Conclusions:

  • Upregulated lncRNAs in EC patients are associated with unfavorable clinicopathological features and poorer survival outcomes.
  • High lncRNA expression levels serve as a detrimental prognostic factor in EC.
  • lncRNAs represent potential biomarkers and therapeutic targets for endometrial carcinoma.