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Hydroxychloroquine in human breast milk.

M Ostensen, N D Brown, P K Chiang

European Journal of Clinical Pharmacology

|January 1, 1985

Summary

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Hydroxychloroquine was detected in breast milk following maternal administration. This finding is crucial for understanding drug transfer during breastfeeding and informing infant safety assessments.

Area of Science:

Pharmacology
Lactation Studies
Drug Metabolism

Background:

Hydroxychloroquine is commonly prescribed for autoimmune conditions.
Limited data exists on hydroxychloroquine transfer into human breast milk.
Assessing infant exposure is vital for drug safety during lactation.

Purpose of the Study:

To quantify hydroxychloroquine levels in breast milk.
To evaluate potential infant exposure to hydroxychloroquine via breastfeeding.

Main Methods:

A single lactating woman received hydroxychloroquine (800 mg over 48 hours).
Breast milk samples were collected and analyzed for hydroxychloroquine concentration.

Main Results:

Hydroxychloroquine was detected in breast milk at a concentration of 3.2 micrograms.

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This indicates measurable drug transfer from mother to infant.

Conclusions:

Hydroxychloroquine is present in breast milk following maternal treatment.
Further research is needed to determine the clinical significance of these levels for breastfeeding infants.