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Updated: May 23, 2025
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
Pedal acceleration time is related to arterial stiffness in patients with chronic limb-threatening ischemia
Daniel Mendes-Pinto1, Larissa Jardim Melo2, Guilherme Galvone Fonseca Costa2
1Hospital Felício Rocho, Belo Horizonte, MG, Brasil.
Insights
Pedal acceleration time (PAT) correlates with arterial stiffness in patients with chronic limb-threatening ischemia (CLTI). These findings help quantify limb ischemia severity.
Area of Science:
- Vascular Medicine
- Cardiovascular Research
- Peripheral Artery Disease
Background:
- Pedal acceleration time (PAT) is a novel indicator for peripheral arterial disease.
- Elevated PAT is linked to severe limb ischemia.
- Arterial stiffness indexes are also studied in chronic limb-threatening ischemia (CLTI).
Purpose of the Study:
- To investigate the correlation between PAT and arterial stiffness indexes in CLTI patients.
Main Methods:
- Cross-sectional analysis of 55 CLTI patients (Aug-Dec 2022).
- PAT measured via vascular ultrasound; stiffness via brachial artery oscillometry.
- Correlations analyzed between blood pressure, stiffness indexes, and PAT.
Main Results:
- Positive correlations found between PAT and pulse wave velocity (PWV) (r=0.69, p<0.001).
- Positive correlation between PAT and augmentation index (AIx@75) (r=0.59, p<0.001).
- Inverse relationship between PAT and ankle-brachial index (r=-0.79, p<0.001).
Conclusions:
- Arterial stiffness indexes correlate with PAT in CLTI patients.
- These indicators are valuable for quantifying limb ischemia.
Background:
Pedal acceleration time (PAT) is a novel indicator of peripheral arterial disease in the lower limbs. Elevated PAT values are associated with worse limb ischemia. Arterial stiffness indexes are another class of indicators recently studied in patients with chronic limb-threatening ischemia (CLTI). The correlation between PAT and arterial stiffness has not yet been established.
Objectives:
To analyze correlations between PAT and arterial stiffness indexes in patients with CLTI.
Methods:
A cross-sectional analysis was conducted of patients with CLTI from August to December of 2022. The PAT measurements were performed using a vascular ultrasound machine and stiffness indexes were measured using a brachial artery oscillometry unit. An analysis was conducted of the correlations between central blood pressure, peripheral blood pressure, arterial stiffness, and PAT.
Results:
A total of 55 patients were analyzed, of whom 23 were women and 83.6% had diabetes. Mean PAT was 166.6 ms; mean pulse wave velocity (PWV) was 11.8 m/s, and the mean augmentation index corrected for a heart rate of 75 beats per minute (AIx@75) was 29.8%. There were positive correlations between PAT and PWV (Spearman r = 0.69; p < 0.001) and between PAT and AIx@75 (Spearman r = 0.59, p < 0.001) and an inverse relationship with the ankle/brachial index (Spearman r = -0.79; p < 0.001).
Conclusions:
There is a correlation between arterial stiffness indexes and PAT in patients with CLTI. These indicators are important for quantification of limb ischemia.
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