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Updated: May 23, 2025
Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids
Published on: May 12, 2023
A bacteria-based bioorthogonal platform disrupts the flexible lipid homeostasis for potent metabolic therapy
Jiadai Yi1,2, Huan Wang1, Qingqing Deng1,2
1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China huanwang@ciac.ac.cn jren@ciac.ac.cn xqu@ciac.ac.cn.
Abstract:
Cancer cells exhibit altered metabolism and energetics, prominently reprogramming lipid metabolism to support tumor growth and progression, making it a promising target for cancer therapy. However, traditional genetic and pharmaceutical approaches for disrupting lipid metabolism face challenges due to the adaptability of tumor metabolism and potential side effects on normal tissues. Here, we present a bacteria-based bioorthogonal platform combining transition metal catalysts and Lactobacillus to disrupt the flexible lipid homeostasis in tumors. This platform activates glutamine transporter inhibitors in situ, targeting lipid synthesis in hypoxic tumor environments, while Lactobacillus inhibits lipid accumulation. By disrupting lipid metabolism and glutamine utilization, the present study proposes a safe and potent strategy for cancer therapy, with potential applications for other metabolic diseases.
Insights
This study introduces a novel bacteria-based therapy to disrupt cancer cell lipid metabolism. The platform targets tumor lipid synthesis and accumulation, offering a safe and effective cancer treatment strategy.
Area of Science:
- Biochemistry
- Oncology
- Microbiology
Background:
- Cancer cells reprogram lipid metabolism for growth, presenting a therapeutic target.
- Existing therapies face challenges due to metabolic adaptability and side effects.
Purpose of the Study:
- To develop a bacteria-based bioorthogonal platform for disrupting tumor lipid metabolism.
- To target lipid synthesis and accumulation in hypoxic tumor environments.
Main Methods:
- Utilized a platform combining transition metal catalysts and *Lactobacillus*.
- Activated glutamine transporter inhibitors *in situ* to target lipid synthesis.
- *Lactobacillus* was employed to inhibit lipid accumulation.
Main Results:
- Successfully disrupted lipid homeostasis in tumors.
- Targeted lipid synthesis in hypoxic tumor regions.
- Inhibited lipid accumulation via *Lactobacillus*.
Conclusions:
- The bacteria-based platform offers a safe and potent strategy for cancer therapy.
- Disrupting lipid metabolism and glutamine utilization is key.
- Potential applications extend to other metabolic diseases.
