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Sleep dysfunction in aspirin exacerbated respiratory disease: A prospective cohort study
David J Cvancara1, Mohamed A Aboueisha1, Ayush A Sharma1
1Department of Otolaryngology-Head and Neck Surgery University of Washington School of Medicine Seattle Washington USA.
World Journal of Otorhinolaryngology - Head and Neck Surgery
|March 12, 2025
Summary
Patients with aspirin-exacerbated respiratory disease (AERD) experience significantly higher rates of severe sleep dysfunction (SD) compared to those with chronic rhinosinusitis (CRS). This study highlights the increased burden of SD in AERD, independent of other sleep quality factors.
Area of Science:
- Otolaryngology
- Sleep Medicine
- Immunology
Background:
- Sleep dysfunction (SD) is recognized in chronic rhinosinusitis (CRS) patients.
- Limited research exists on SD within aspirin-exacerbated respiratory disease (AERD).
Purpose of the Study:
- To investigate the prevalence and severity of SD in AERD patients.
- To compare SD in AERD patients against those with CRS (with and without nasal polyposis).
Main Methods:
- Prospective cohort study involving 206 CRSsNP, 38 CRSwNP, and 28 AERD patients.
- Sleep dysfunction assessed using the Neuro-QOL Short Form v1.0-Sleep Disturbance (sleep-QOL).
- Statistical analyses (univariate and multivariate) adjusted for demographic and patient-reported outcomes (SNOT-22, PHQ-2).
Main Results:
- Severe SD prevalence was significantly higher in AERD (57.1%) versus CRSsNP (32.5%) and CRSwNP (34.2%).
- Adjusted analyses confirmed a higher risk of SD in AERD patients (OR 2.72 vs. CRSsNP, OR 3.06 vs. CRSwNP).
- No correlation found between SNOT-22 scores and sleep-QOL scores.
Conclusions:
- AERD patients exhibit greater frequency and severity of SD than CRS patients, irrespective of confounding factors.
- The underlying mechanism linking AERD and SD requires further investigation.
- SD may be more prevalent in AERD than previously understood.
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