Related Experiment Video

Updated: May 23, 2025

Dual-color Correlative Light and Electron Microscopy for the Visualization of Interactions between Mitochondria and Lysosomes
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Dual-color Correlative Light and Electron Microscopy for the Visualization of Interactions between Mitochondria and Lysosomes

Published on: September 27, 2024

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MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological

Yang Wang1, Wei Wei1, Yu Zhang1

  • 1School of Pharmacy, Nantong University, Nantong, Jiangsu, China.

Frontiers in Pharmacology
|March 12, 2025
PubMed

Insights

Mixed lineage kinase domain-like protein (MLKL) regulates cellular organelles beyond necroptosis. This review explores MLKL

Area of Science:

  • Cellular Biology
  • Molecular Mechanisms
  • Drug Discovery

Background:

  • Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase known for its role in necroptosis.
  • Recent studies reveal MLKL's involvement with various cellular organelles, including mitochondria, lysosomes, and the nucleus.
  • This contrasts with its established function in plasma membrane permeabilization during necroptosis.

Purpose of the Study:

  • To review the regulatory functions, mechanisms, and targets of MLKL within cellular organelles.
  • To summarize the medical significance of MLKL in diverse diseases.
  • To analyze the current progress and future prospects for MLKL-targeted drug development.

Main Methods:

  • Literature review focusing on MLKL's organelle functions.
  • Analysis of existing data on MLKL's role in disease pathology.
  • Evaluation of therapeutic strategies targeting MLKL.

Main Results:

  • MLKL exhibits diverse regulatory roles across multiple cellular organelles.
  • MLKL's involvement extends beyond necroptosis to other cellular processes.
  • Significant medical implications of MLKL in various diseases are identified.

Conclusions:

  • MLKL is a versatile protein with critical functions in cellular organelles.
  • Targeting MLKL presents a promising therapeutic avenue for multiple diseases.
  • Development of MLKL-specific drugs, including natural products and PROTACs, is advancing.
Keywords:
MLKLdisease targetnatural productsorganelle dynamicssmall-molecule chemicals

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