Concomitant Graves' Disease and Ulcerative Colitis

It is widely recognized that one autoimmune disorder is sometimes associated with an increased frequency of having another autoimmune condition. However, the simultaneous presentation of Ulcerative colitis and Graves' disease is an underreported occurrence in the medical literature. We present the case of a previously healthy 36-year-old female who presented with acute symptoms of ulcerative colitis and Graves' disease simultaneously, leading to the diagnosis of both conditions within a short time frame. These diagnoses were supported by colonoscopy findings of diffuse colonic inflammation along with low thyroid-stimulating hormone and elevated thyroxine levels. Her symptoms of both Graves' disease and ulcerative colitis rapidly resolved with treatment of Graves' disease. This case highlights the significance of developing a broad differential and considering the coexistence of multiple autoimmune conditions when systemic symptoms are present.