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Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report
Xiaofei Deng1, Yong Luo2, Qin Yang1
1Department of Oncology, Yingshan County People's Hospital, Nanchong, Sichuan 637000, P.R. China.
Oncology Letters
|March 12, 2025
Summary
This case study highlights a rare instance of primary gingival diffuse large B-cell lymphoma (DLBCL) invading muscle. The patient achieved stable disease for six years before experiencing recurrence, emphasizing the need for individualized treatment strategies.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary extranodal lymphoma, specifically diffuse large B-cell lymphoma (DLBCL), is uncommon.
- Gingival DLBCL with muscle invasion represents a rare subtype, accounting for approximately 0.5% of extranodal lymphoma cases.
Observation:
- A 49-year-old male presented with jaw swelling and tenderness, diagnosed as gingival DLBCL.
- Initial treatment with R-CHOP, R-CHOEP, and SYHX1903 resulted in stable disease for six years.
- Recurrence involving forearm muscle invasion was confirmed via biopsy after trauma.
Findings:
- The gingival DLBCL was characterized by positivity for CD20, BCL-6, BCL-2, C-MYC, and MUM1.
- Despite initial treatment success, the lymphoma demonstrated invasive potential into muscle tissue.
- Palliative radiotherapy led to a partial response in the forearm lesion.
Implications:
- Primary gingival DLBCL with muscle invasion is rare and prone to misdiagnosis.
- Individualized treatment approaches are crucial for managing such complex and rare oncological presentations.
- This case underscores the importance of thorough diagnostic workup for persistent or unusual symptoms, even after initial treatment success.
