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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Published on: June 21, 2018

Interleukin-1β and Tumor Necrosis Factor-α Gene Polymorphisms in Systemic Sclerosis

M A Hakami1, B S Alotaibi1, S S Alkhalil1

  • 1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al- Quwayiyah, Shaqra University - 19254, Riyadh, Saudi Arabia.

Balkan Journal of Medical Genetics : BJMG
|March 12, 2025
PubMed
Summary

Single-nucleotide polymorphisms (SNPs) in interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) genes are associated with systemic sclerosis (SSc) susceptibility. Further research is needed to confirm the role of these cytokine gene SNPs in SSc development.

Keywords:
AutoimmunityCytokinesDisease developmentGenotypingPredisposition

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