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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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The Association of the Metabolic Score for Insulin Resistance (METS-IR) with Prehypertension in Normoglycemic

Methaq H Alogaili1, Afnan A Alsallami2

  • 1Deptartment of Family and Community Medicine, College of Medicine, Al-Nahrain University, Baghdad, Iraq.

International Journal of Endocrinology and Metabolism
|March 12, 2025
PubMed
Abstract

Insights

The metabolic score for insulin resistance (METS-IR) is a significant predictor of prehypertension in individuals with normal blood glucose. This simple score can help identify those at risk for developing high blood pressure.

Area of Science:

  • Metabolic health and cardiovascular disease risk assessment.
  • Endocrinology and metabolic syndrome research.
  • Public health and preventative medicine strategies.

Background:

  • Insulin resistance is a key factor in chronic diseases like diabetes and hypertension.
  • Early detection of insulin resistance is crucial for disease prevention.
  • A simple, inexpensive method for detecting insulin resistance is needed.

Purpose of the Study:

  • To evaluate the association between the metabolic score for insulin resistance (METS-IR) and prehypertension in individuals with normal blood glucose.
  • To determine if METS-IR can predict the development of prehypertension.

Main Methods:

  • A cross-sectional study compared 179 normoglycemic adults with prehypertension to 179 age- and sex-matched controls without prehypertension.
  • Individuals with a history of hypertension, diabetes, CAD, or on chronic medication were excluded.
  • METS-IR was calculated using fasting plasma glucose, fasting triglycerides, BMI, and HDL-c.

Main Results:

  • The METS-IR score was significantly higher in the prehypertension group (P < 0.001).
  • BMI, triglycerides, and HDL-c showed significant differences across METS-IR quartiles.
  • METS-IR independently predicted prehypertension (OR = 1.3, 95% CI 1.20–1.34).

Conclusions:

  • The metabolic score for insulin resistance (METS-IR) is significantly associated with prehypertension in euglycemic individuals.
  • METS-IR serves as an independent predictor of prehypertension.
  • This score offers a valuable tool for early risk identification.
Keywords:
Cross-Sectional StudyInsulin ResistanceMETS-IRPrehypertension

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