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Updated: May 22, 2025

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
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New antibiotics targeting Gram-negative bacilli.

Jaffar A Al-Tawfiq1,2,3, Ranjit Sah4,5,6, Rachana Mehta7,8

  • 1Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

Le Infezioni in Medicina
|March 12, 2025
PubMed
Summary
This summary is machine-generated.

New antibiotics are in development to combat antimicrobial resistance (AMR), a growing global health crisis. However, limited options exist for high-priority resistant bacteria, necessitating urgent innovation.

Keywords:
Antibioticsantibiotic resistancemulti-drug-resistancenew antibioticsnovel antibioticspipeline

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, increasing mortality and healthcare costs.
  • Responsible antibiotic use and new drug development are crucial strategies for healthcare professionals to combat AMR.

Purpose of the Study:

  • To review newly developed antibiotics in the pipeline.
  • To assess their development status, mechanism of action, activity spectrum, and approved indications.

Main Methods:

  • Literature review of Medline and ClinicalTrials.org for approved and pipeline antibiotics in Phase 3 or New Drug Application (NDA) stages.
  • Analysis of data from Phase 3 clinical trials.

Main Results:

  • Several new antibiotics have been identified, with many targeting common infections like skin and pneumonia.
  • Limited availability of new agents against high-priority resistant organisms was observed.
  • Most new antibiotics are based on existing molecules or agents.

Conclusions:

  • While new antibiotics are emerging, there is an urgent need for agents effective against high-priority resistant organisms, including ESBL-producing Enterobacterales, carbapenem-resistant Enterobacterales, *Acinetobacter baumannii*, and *Pseudomonas aeruginosa*.
  • Current development focuses on addressing existing threats, but innovation for critical pathogens remains insufficient.