FV-429 suppresses cancer cell migration and invasion by EMT via the Hippo/YAP1 pathway in pancreatic cancer cells
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View abstract on PubMed
Summary
This summary is machine-generated.FV-429, a wogonin derivative, inhibits pancreatic cancer metastasis by targeting the Hippo/YAP1 pathway. This compound reduces cell invasion and migration by modulating epithelial-mesenchymal transition (EMT) proteins, showing therapeutic potential with high safety.
Area Of Science
- Oncology
- Molecular Biology
- Pharmacology
Background
- Pancreatic cancer frequently metastasizes, leading to patient mortality.
- Epithelial-mesenchymal transition (EMT) drives tumor cell migration and invasion.
- Yes-associated protein 1 (YAP1) is oncogenic and overexpressed in many cancers.
Purpose Of The Study
- To investigate the antimetastatic effects of FV-429, a wogonin derivative, on pancreatic cancer.
- To elucidate the mechanism of FV-429 action via the Hippo/YAP1 pathway and its impact on EMT.
Main Methods
- In vitro studies using pancreatic cancer cells to assess invasion and migration.
- Analysis of EMT-related protein expression (p-LATS1, p-YAP1, E-cadherin, snail1).
- In vivo validation using a mouse model of pancreatic cancer lung metastasis.
Main Results
- FV-429 inhibited pancreatic cancer cell invasion and metastasis.
- FV-429 promoted p-LATS1 and p-YAP1 expression, suppressing YAP1 nuclear translocation.
- FV-429 modulated E-cadherin and snail1, impacting EMT and confirming Hippo/YAP1 pathway involvement.
- FV-429 demonstrated high safety and low toxicity in vivo.
Conclusions
- FV-429 effectively inhibits pancreatic cancer cell migration, invasion, and metastasis.
- The mechanism involves modulation of the Hippo/YAP1 pathway and EMT.
- FV-429 shows promise as a novel therapeutic agent for pancreatic cancer.
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