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Patients' experiences with GLP1-RAs - a systematic review

Christoffer Kraul Ibsen1, Marius Brostrøm Kousgaard1, Sofie Olsen1

  • 1Center for General Practice, University of Copenhagen, Copenhagen, Denmark.

Scandinavian Journal of Primary Health Care
|March 12, 2025
PubMed
Abstract

Insights

Patients using glucagon-like peptide-1 receptor agonists (GLP1-RAs) for obesity accept side effects for weight loss and report improved well-being. Understanding patient experiences with these popular obesity medications is crucial.

Area of Science:

  • Metabolic disorders
  • Pharmacology
  • Patient-reported outcomes

Background:

  • Obesity is a significant public health issue with limited effective treatments.
  • Glucagon-like peptide-1 receptor agonists (GLP1-RAs) show promise for significant weight loss.
  • Patient experiences with GLP1-RAs are not well understood.

Purpose of the Study:

  • To systematically review existing research on patient experiences with GLP1-RAs.
  • To synthesize qualitative and quantitative data on patient perspectives regarding GLP1-RAs for obesity management.

Main Methods:

  • Comprehensive literature search across major databases (PubMed, PsycINFO, Embase, Sociological Abstracts).
  • Inclusion of studies on adult GLP1-RA users, excluding specific conditions like mental illness or PCOS.
  • Thematic analysis of nine selected studies (qualitative, RCTs, reviews, survey) to synthesize findings.

Main Results:

  • Patients tolerate adverse events, such as gastrointestinal issues, for successful weight loss.
  • Weight loss achieved with GLP1-RAs leads to improved physical functioning and daily living.
  • Patient experiences vary regarding medication usability, craving management, and gender-specific benefits.

Conclusions:

  • Qualitative research on GLP1-RA patient experiences is limited despite high demand.
  • Further research is essential to fully comprehend short- and long-term patient journeys with GLP1-RAs.
  • Understanding patient perspectives can optimize obesity treatment strategies.
Keywords:
GLP1-RALived experiencesperceptionperspectivesystematic review

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