Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antiepileptic drugs: detection, quantification, and evaluation.

E A Swinyard, H J Kupferberg

    Federation Proceedings
    |July 1, 1985
    PubMed
    Summary

    Laboratory tests can identify anticonvulsant potential by measuring effects on seizure threshold and spread. Standardized in vivo methods reliably predict the clinical effectiveness of antiepileptic drugs.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Further studies on the anticonvulsant properties of tridione (3,5,5-trimethyloxazolidinedione).

    Federation proceedings·2010
    Same author

    The effects of body water and electrolyte shifts on experimental convulsions.

    Federation proceedings·2010
    Same author

    Laboratory assay of anticonvulsant potency of some hydantoinates.

    Federation proceedings·2010
    Same author

    Observations on the central excitatory effects of metrazol.

    Federation proceedings·2010
    Same author

    Some properties of maximal electroshock seizures.

    Federation proceedings·2010
    Same author

    A comparison of time relations in convulsive and nonconvulsive responses to cortical stimulation.

    Federation proceedings·2010

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Drug Discovery

    Background:

    • Anticonvulsant potential is assessed via tests targeting various biological levels.
    • Procedures focus on modifying electrochemical or neurochemical events, or seizure spread.
    • Effective antiepileptic drug (AED) testing requires identifying substances that elevate seizure threshold or prevent seizure spread.

    Purpose of the Study:

    • To outline laboratory tests for identifying and evaluating anticonvulsant potential.
    • To emphasize the importance of standardized procedures for reliable and reproducible results.
    • To validate in vivo methods for predicting clinical utility of AEDs.

    Main Methods:

    • Utilizing subcutaneous Metrazol (pentylenetetrazol) seizure threshold test.
    • Employing the supramaximal electroshock seizure test.
    • Incorporating additional chemoshock tests to explore mechanisms of action.

    Main Results:

    • Standardized in vivo procedures are reliable and reproducible.
    • These methods effectively predict the clinical utility of tested drugs.
    • New models are validated against clinically effective AEDs identified by established procedures.

    Conclusions:

    • Laboratory tests are crucial for detecting and evaluating anticonvulsant activity.
    • Controlled variables in testing ensure accurate and reproducible results.
    • Established in vivo models remain valuable for AED discovery and evaluation.

    Related Experiment Videos