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Exercise and Psychosexual Education to Improve Sexual Function in Men With Prostate Cancer: A Randomized Clinical
Daniel A Galvão1,2, Robert U Newton1,2, Dennis R Taaffe1,2
1Exercise Medicine Research Institute, Edith Cowan University, Perth, Australia.
JAMA Network Open
|March 12, 2025
Summary
Supervised exercise significantly improved erectile function in men undergoing prostate cancer treatment. This approach offers a valuable rehabilitation strategy, enhancing physical health alongside sexual function recovery.
Area of Science:
- Oncology
- Urology
- Exercise Science
Background:
- Sexual dysfunction is a prevalent side effect of prostate cancer treatments.
- Current management strategies often fail to address the complex physical and psychological factors contributing to sexual dysfunction.
- Exercise presents a promising therapeutic avenue for managing sexual dysfunction in this population.
Purpose of the Study:
- To evaluate the impact of supervised, clinic-based resistance and aerobic exercise on sexual function in men with prostate cancer.
- To assess the added benefits of a brief psychosexual education and self-management intervention (PESM) combined with exercise.
- To compare these interventions against usual care in improving sexual function and other health parameters.
Main Methods:
- A 3-arm, parallel-group, randomized clinical trial involving 112 men with prostate cancer experiencing sexual dysfunction concerns.
- Participants were assigned to 6 months of supervised exercise, supervised exercise plus PESM, or usual care.
- The primary outcome measure was sexual function assessed using the International Index of Erectile Function (IIEF).
Main Results:
- Supervised exercise demonstrated a statistically significant improvement in erectile function (IIEF scores) compared to usual care (mean difference 3.5, P=0.04).
- Exercise also led to significant improvements in fat mass, chair rise performance, and upper and lower body muscle strength.
- The addition of PESM did not yield additional benefits in sexual function or other measured outcomes.
Conclusions:
- Supervised exercise is an effective intervention for improving erectile function in men treated for prostate cancer.
- Exercise programs should be considered as a rehabilitation measure for patients with prostate cancer.
- The PESM intervention, in this trial, did not provide added value to the exercise program for sexual function outcomes.
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