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Updated: May 22, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Modeling charge collection in silicon pixel detectors for proton therapy applications
Alexander Schilling1, Max Aehle1, Johan Alme2
1Chair for Scientific Computing, University of Kaiserslautern-Landau (RPTU), 67663 Kaiserslautern, Germany.
Optimizing charge diffusion models improves accuracy in proton computed tomography and range verification. Application-specific models, like power law for pCT and Cauchy-Lorentz for range verification, enhance performance with ALICE PIxel DEtector (ALPIDE) telescopes.
Area of Science:
- Particle Physics
- Medical Physics
- Detector Technology
Background:
- Monolithic active pixel sensors are crucial for charged particle tracking in diverse fields.
- The ALICE PIxel DEtector (ALPIDE) is utilized in proton computed tomography (pCT) and particle therapy range verification.
- Accurate charge diffusion modeling is essential for interpreting energy deposition in pixel detectors.
Purpose of the Study:
- To optimize charge diffusion models for pCT and in-situ range verification using ALPIDE sensors.
- To evaluate the impact of different charge diffusion models on downstream application performance.
- To identify the most effective diffusion models for specific applications.
Main Methods:
- Experimental data from the Danish Centre for Particle Therapy was used for model optimization.
- Parameters of various charge diffusion models were fitted to experimental data.
- Downstream task performance was assessed to quantify the impact of charge diffusion modeling.
Main Results:
- Application-specific charge diffusion models yield superior results compared to generic models.
- A power law model demonstrated optimal performance for proton computed tomography.
- A 2D Cauchy-Lorentz distribution model provided better agreement for proton range verification.
- Evaluating downstream tasks with multiple approaches is critical for performance metric estimation.
Conclusions:
- Charge diffusion model selection significantly influences the performance of particle tracking applications.
- A 2D Cauchy-Lorentz distribution model is recommended for proton range verification with ALPIDE pixel telescopes.
- Optimized, application-specific diffusion models enhance the utility of ALPIDE-based pixel telescopes.
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