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Can apelins guide the diagnosis of coronary artery disease in COPD patients?
Alperen Aksakal1, Buğra Kerget1, Burcu Nur Gülbahar1
1Depertment of Pulmonary Diseases, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.
Insights
Serum apelin levels are lower in patients with chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD). Apelin may help diagnose CAD in COPD patients.
Area of Science:
- Cardiovascular Research
- Pulmonary Medicine
- Biomarker Discovery
Background:
- Apelin, an adipokine, exhibits anti-inflammatory and antiatherosclerotic properties.
- Apelin is implicated in chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) pathogenesis.
Purpose of the Study:
- To evaluate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.
- To investigate the association between serum apelin levels and the presence of CAD in COPD.
Main Methods:
- Serum apelin levels (apelin 12, 13, 17, 36) were measured in 73 stable COPD patients and 35 healthy controls using ELISA.
- COPD patients were stratified into groups with and without CAD.
Main Results:
- Serum apelin levels were significantly lower in COPD patients compared to controls.
- COPD patients with CAD exhibited lower serum apelin levels than those without CAD.
- Apelin 13 and 36 demonstrated high sensitivity and specificity for predicting CAD in COPD patients.
Conclusions:
- Serum apelin, particularly apelin 13 and 36, shows promise as a biomarker for early CAD detection in COPD patients.
- Early diagnosis and management of CAD are crucial for improving prognosis in COPD patients.
Background:
Apelins are adipokines known for their anti-inflammatory, vasodilator, and antiatherosclerotic effects. They are involved in the pathogenesis of chronic diseases like chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD).
Objectives:
This study aims to investigate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.
Methods:
The study included 73 stable COPD patients admitted between June 2023 and June 2024 and 35 healthy volunteers matched by age and gender. COPD patients were categorized into two groups: those without CAD (Group 1) and those with CAD (Group 2). Serum levels of apelin 12, 13, 17, and 36 were measured using ELISA.
Results:
Serum apelin levels were significantly lower in COPD patients than in controls (p < 0.001). Among COPD patients, those with CAD showed lower serum apelin levels compared to those without CAD (p = 0.005 for apelin 12, p < 0.001 for apelin 13, 17, and 36). ROC analysis indicated high sensitivity and specificity for apelin 13 and 36 in predicting CAD in COPD patients. Apelin 13 and 36 were positively correlated with ejection fraction (EF) (R = 0.43, p = 0.01; R = 0.4, p = 0.01), and apelin 12 was positively correlated with FEV1 and FVC (R = 0.24, p = 0.04; R = 0.27, p = 0.02).
Conclusion:
While CAD worsens the prognosis in COPD patients, it remains underdiagnosed. Serum apelin, especially apelin 13 and 36, may assist in the early diagnosis and management of CAD in COPD patients.
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