People entering opioid substance use treatment have low rates of naloxone knowledge and possession
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Naloxone possession and knowledge are higher among individuals with high-risk opioid use behaviors and overdose history. However, significant gaps persist, underscoring the need for expanded naloxone access and education.
Area Of Science
- Public Health
- Addiction Medicine
- Pharmacology
Background
- Opioid overdose deaths are a critical public health crisis in the United States.
- Naloxone (opioid antagonist) distribution is a key strategy to reduce mortality.
- Understanding factors associated with naloxone possession and knowledge is crucial for targeted interventions.
Purpose Of The Study
- To assess the association between high-risk behaviors and naloxone possession.
- To determine the relationship between high-risk behaviors and knowledge of naloxone availability.
- To identify gaps in naloxone access among individuals with opioid use disorder.
Main Methods
- Cross-sectional survey of 5663 adults entering opioid use disorder treatment in the US in 2022.
- Logistic regression analysis to compare naloxone possession and knowledge based on self-reported opioid use patterns and overdose history.
- Analysis of data stratified by routes of opioid administration and types of opioids used.
Main Results
- Individuals reporting fentanyl, heroin, or multiple opioid types had higher naloxone possession rates than those using oxycodone alone.
- Injection drug users were more likely to possess (61%) and know where to find (77%) naloxone compared to non-injectors (44% and 58%, respectively).
- Those with a history of overdose were more likely to possess (59%) and know where to find (77%) naloxone than those without (42% and 55%, respectively).
Conclusions
- Gaps in naloxone possession and awareness persist among patients in opioid use disorder treatment.
- Targeted educational programs and community-based organization involvement are needed to expand naloxone ownership.
- Bystander training is recommended to improve naloxone accessibility and overdose response.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...