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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Related Experiment Video

Updated: May 22, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Treatable Trait Guided Asthma Management: A Feasibility Study.

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Personalised medicine for asthma is feasible and acceptable, showing clinical benefits. However, targeting specific traits like type-2 inflammation was insufficient for full asthma control in most patients.

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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Personalised Medicine

Background:

  • Treatable trait-based personalised medicine has shown success in severe asthma management.
  • The feasibility of applying this approach outside of specialized severe asthma clinics is not well established.

Purpose of the Study:

  • To assess the feasibility of a randomized controlled trial (RCT) for protocolized treatable trait-guided asthma management in patients not attending a severe asthma clinic.
  • To evaluate recruitment rates, intervention acceptability, and willingness to enroll in a future RCT.

Main Methods:

  • A 10-week, single-group cohort study involving participants with diagnosed asthma, uncontrolled symptoms (ACQ-5 score >1), and recent exacerbations.
  • Biomarker-guided asthma medication adjustments based on a protocol targeting type-2 inflammation and airflow obstruction.
  • Feasibility outcomes included recruitment, acceptability, willingness for RCT enrollment, need for extended trait assessment, and trait prevalence estimation.

Main Results:

  • Recruitment achieved 29/50 participants over 14 months, with a 25% invitation acceptance rate, impacted by COVID-19.
  • 92% of participants found the intervention acceptable and were willing to join a future RCT.
  • Despite improvements in Asthma Control Questionnaire-5 (ACQ-5) scores and reduced airflow limitation, 65% remained uncontrolled, necessitating extended assessment. 41% required continuous oral corticosteroids.

Conclusions:

  • Protocolized treatable trait management is acceptable and offers clinical benefits, supporting the feasibility of a full RCT.
  • Targeting type-2 inflammation and airflow obstruction alone was insufficient for achieving asthma control in most participants.
  • Significant systemic corticosteroid exposure was noted, highlighting the need for further research into comprehensive asthma management strategies.