Unveiling the hemispheric specialization of language: Organization and neuroplasticity

The advancements in understanding hemispheric specialization of language (HSL) have been following two primary avenues: the development of neuroimaging techniques and the study of its reorganizations in patients with various neuropathologic conditions. Hence, the objectives of this chapter are twofold. First, to provide an overview of the key neuroimaging techniques employed to investigate HSL, along with the notable findings derived from them in the healthy population. Second, it focuses on the reorganization of HSL in physiologic (healthy aging) and pathologic (poststroke aphasia and temporal lobe epilepsy) conditions. The chapter emphasizes the importance of employing multimodal methodologies to comprehend the complex relationship between underlying HSL mechanisms affected by disease and resulting language impairments. Combining the neuroimaging techniques can help us understand how different characteristics of language networks combine into general mechanisms that support their plasticity. Nevertheless, it highlights the need for standardized HSL metrics, as the absence of such metrics poses challenges in synthesizing findings across studies. Additionally, while HSL findings are being accumulated, albeit multimodal, there is a lack of integration within a robust theoretical framework. In conclusion, there is a need for novel models acknowledging multimodal aspects of HSL while positioning it within the context of other cognitive functions.