A Meta-analysis of 68Ga-FAPI PET in Assessment of Ovarian Cancer

The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).

The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies. Bivariate random effects models were utilized to compute the sensitivity and specificity of 68Ga-FAPI PET CT/MR in OC. The I-square index (I²) was utilized to measure heterogeneity and sensitivity analysis were employed to test it.

The pooled sensitivity as well as specificity for 68Ga-FAPI PET CT/MR in OC were 0.90 (95% CI: 0.84-0.95) as well as 0.95 (95% CI: 0.91-0.97), correspondingly. In the subanalysis for metastatic lesions (lymph node [LN] metastases and peritoneal involvement), the pooled sensitivity and specificity of 68Ga-FAPI PET CT/MR were 0.94 (95% CI: 0.74-0.99) and 0.95 (95% CI: 0.84-0.99) for identifying metastatic LNs as well as 0.93 (95% CI: 0.81-0.97) and 0.96 (95% CI: 0.89-0.99) about peritoneal carcinomatosis evaluation, correspondingly. In the head-to-head comparison with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in identifying peritoneal metastases (P=.0004).

68Ga-FAPI PET CT/MR displayed a high overall diagnostic effectiveness in OC. When evaluating metastatic peritoneal lesions of OC, 68Ga-FAPI PET CT/MR displayed a superior pooled sensitivity.