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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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Microfluidics in Assessing Platelet Function
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Conventional Coagulation Tests are a better predictor of mortality than Viscoelastic Haemostatic Assays in trauma

Anten P Jonish1, Joses Dany James1, D K Titus2

  • 1Department of Trauma Surgery, Christian Medical College Vellore, Ranipet Campus, Vellore, Tamil Nadu, India.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
|March 13, 2025
PubMed
Summary
This summary is machine-generated.

Conventional Coagulation Tests (CCTs), particularly INR, are better predictors of mortality in trauma patients than Viscoelastic Haemostatic Assays (VHAs). This finding highlights the prognostic value of CCTs in trauma resuscitation.

Keywords:
Conventional Coagulation Tests (CCTs)Mortality in traumaROTEMViscoelastic Haemostatic Assays (VHAs)

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Area of Science:

  • Trauma resuscitation
  • Coagulation diagnostics
  • Mortality prediction

Background:

  • Conventional Coagulation Tests (CCTs) and Viscoelastic Haemostatic Assays (VHAs) guide trauma resuscitation.
  • The predictive role of these tests for mortality in trauma patients remains less understood.
  • This study investigates the comparative efficacy of CCTs and VHAs in predicting trauma-related mortality.

Purpose of the Study:

  • To analyze the predictive power of Conventional Coagulation Tests (CCTs) and Viscoelastic Haemostatic Assays (VHAs) for mortality in adult trauma patients.
  • To compare the prognostic value of CCTs versus VHAs in a shock trauma cohort.

Main Methods:

  • A prospective observational study included 106 adult trauma patients presenting in shock.
  • Patients underwent both VHA (rotational thromboelastometry) and CCTs.
  • Univariable and multivariable regression analyses were employed to assess mortality prediction.

Main Results:

  • Prolonged INR (>1.66) and prolonged clotting time (>384 s) were significant predictors of mortality.
  • Conventional Coagulation Tests demonstrated a superior ability to predict mortality compared to VHAs.
  • Specifically, INR emerged as a more reliable mortality predictor than VHA parameters.

Conclusions:

  • Conventional Coagulation Tests, particularly INR, are more reliable predictors of mortality in trauma patients than VHAs.
  • CCTs offer significant prognostic value in trauma care.
  • Integrating both CCTs and VHAs may enhance trauma patient assessment and management strategies.