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Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention

Fiona Ecarnot1,2, Jotheeswaran Amuthavalli Thiyagarajan3, Mario Barbagallo4

  • 1SINERGIES Unit, University Marie & Louis Pasteur, 19 rue Ambroise Paré, Besançon, 25000, France. Fiona.ecarnot@Univ-fcomte.fr.

Aging Clinical and Experimental Research
|March 13, 2025
PubMed

Insights

Vaccines for common infectious diseases like influenza and COVID-19 offer significant benefits for cardiovascular and cerebrovascular health, particularly in older adults and those with comorbidities.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Cardiology

Background:

  • Cardiovascular and infectious diseases are leading global causes of mortality.
  • A complex, bidirectional relationship exists between infection and cardiovascular disease pathophysiology.
  • Older adults and individuals with comorbidities are at higher risk for both severe infections and cardiovascular events.

Purpose of the Study:

  • To review current evidence on the link between cardiovascular/cerebrovascular health and common infectious diseases.
  • To evaluate the role of vaccines in preventing infections and their cardiovascular consequences.
  • To synthesize findings from a June 2024 meeting of the European Interdisciplinary Council on Aging (EICA) and SIPREC.

Main Methods:

  • Review of existing scientific literature on vaccine benefits for cardio- and cerebrovascular health.
  • Expert discussion and consensus-building during a 2-day scientific meeting.
  • Synthesis of evidence regarding infectious disease impact on cardiovascular outcomes.

Main Results:

  • Vaccines for influenza, pertussis, pneumococcal disease, herpes zoster, COVID-19, and respiratory syncytial virus (RSV) are recommended for older adults and those with comorbidities.
  • Substantial evidence supports the positive impact of vaccination on cardio- and cerebrovascular health.
  • Vaccination is a key strategy for mitigating the adverse cardiovascular effects of infectious diseases.

Conclusions:

  • Vaccination is a critical preventive measure for both infectious diseases and their associated cardiovascular and cerebrovascular complications.
  • Public health recommendations for adult vaccination align with cardiovascular disease prevention strategies.
  • Further emphasis on vaccination can improve cardiovascular outcomes in vulnerable populations.

Keywords:
COVIDCardiovascularCerebrovascularHerpes zosterInfluenzaPneumococcal diseaseRespiratory syncytial virusSARS-CoV-2Vaccination

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