A Scoping Review of Infrared Spectroscopy and Machine Learning Methods for Head and Neck Precancer and Cancer...

This scoping review aimed to provide both researchers and practitioners with an overview of how machine learning (ML) methods are applied to infrared spectroscopy for the diagnosis and prognosis of head and neck precancer and cancer.

A subject headings and keywords search was conducted in MEDLINE, Embase, and Scopus on 14 January 2024, using predefined search algorithms targeting studies that integrated infrared spectroscopy and ML methods in head and neck precancer/cancer research. The results were managed through the COVIDENCE systematic review platform.

Fourteen studies met the eligibility criteria, which were defined by IR spectroscopy techniques, ML methodology, and a focus on head and neck precancer/cancer research involving human subjects. The IR spectroscopy techniques used in these studies included Fourier transform infrared (FTIR) spectroscopy and imaging, attenuated total reflection-FTIR, near-infrared spectroscopy, and synchrotron-based infrared microspectroscopy. The investigated human biospecimens included tissues, exfoliated cells, saliva, plasma, and urine samples. ML methods applied in the studies included linear discriminant analysis (LDA), principal component analysis with LDA, partial least squares discriminant analysis, orthogonal partial least squares discriminant analysis, support vector machine, extreme gradient boosting, canonical variate analysis, and deep reinforcement neural network. For oral cancer diagnosis applications, the highest sensitivity and specificity were reported to be 100%, the highest accuracy was reported to be 95-96%, and the highest area under the curve score was reported to be 0.99. For oral precancer prognosis applications, the highest sensitivity and specificity were reported to be 84% and 79%, respectively.

This review highlights the promising potential of integrating infrared spectroscopy with ML methods for diagnosing and prognosticating head and neck precancer and cancer. However, the limited sample sizes in existing studies restrict generalizability of the study findings. Future research should prioritize larger datasets and the development of advanced ML models to enhance reliability and robustness of these tools.