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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Long-Term Outcomes in Crosslinking Therapy for Patients with Progressive Keratoconus.

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Corneal crosslinking (CXL) effectively halts progressive keratoconus and reduces astigmatism in mid- to long-term follow-up. While visual acuity remained stable, CXL significantly improved corneal topography, demonstrating its value in managing this condition.

Keywords:
corneal cross-linkingepi-offepi-onkeratoconustopography

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Vision Science

Background:

  • Progressive keratoconus poses a significant threat to vision, necessitating effective treatment strategies.
  • Corneal crosslinking (CXL) is a promising therapeutic approach for stabilizing progressive keratoconus.
  • Evaluating the mid- and long-term outcomes of CXL, including both epi-on and epi-off techniques, is crucial for understanding its efficacy.

Purpose of the Study:

  • To assess the mid- and long-term postoperative results of corneal crosslinking (CXL) in patients with progressive keratoconus.
  • To compare the outcomes of epi-on and epi-off CXL techniques.
  • To analyze changes in visual acuity, corneal topography, and keratometric values following CXL treatment.

Main Methods:

  • Retrospective single-center study from October 2013 to July 2020.
  • Inclusion of 290 eyes from 201 patients diagnosed with progressive keratoconus who underwent CXL.
  • Analysis of preoperative and postoperative autorefractometry, visual acuity, endothelial cell counts, and corneal topography at 6-12 months and 1-3 years.

Main Results:

  • Corneal crosslinking (CXL) demonstrated no significant impact on visual acuity.
  • Significant improvements were observed in corneal topographic and keratometric features post-CXL.
  • Substantial decreases in K1, K2, and KM values were recorded, indicating reduced corneal curvature severity.

Conclusions:

  • Corneal crosslinking (CXL) is a vital treatment for keratoconus, preserving vision and reducing astigmatism.
  • CXL effectively halts the progression of keratoconus, offering long-term stability.
  • While both epi-on and epi-off CXL showed positive results, larger, long-term studies are needed for definitive comparisons.