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Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Updated: May 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging

Ho-Ching Yang¹, Tyler Nguyen^2,3, Fletcher A White^2,3

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Diagnostics (Basel, Switzerland)

|March 13, 2025

Summary

This summary is machine-generated.

Diffusion tensor imaging (DTI) reveals early white matter changes in mild traumatic brain injury (mTBI) patients with headaches. These brain microstructural alterations at one month predict long-term pain and psychological issues.

Keywords:

diffusion tensor imaging endogenous pain measure mild traumatic brain injury post-traumatic headache psychological-related assessments

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Last Updated: May 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Diffusion Imaging in the Rat Cervical Spinal Cord

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Area of Science:

Neuroimaging
Neurology
Radiology

Background:

Post-traumatic headaches are common after mild traumatic brain injury (mTBI), impacting quality of life.
The underlying mechanisms of mTBI-related headaches remain poorly understood.
Diffusion tensor imaging (DTI) offers a potential tool to investigate brain changes associated with mTBI.

Purpose of the Study:

To detect brain microstructural changes using DTI in mTBI patients with post-traumatic headaches.
To explore the relationship between DTI metrics and subsequent pain and psychological outcomes.

Main Methods:

Recruited mTBI participants and healthy controls from Level 1 trauma centers.
Acquired MRI scans, including T1-weighted and DTI, one month post-injury.
Collected pain sensitivity assays and psychological assessments at one and six months post-injury.

Main Results:

Observed significant differences in axial diffusivity in the forceps major between mTBI participants and controls one month post-injury (p=0.02).
Found significant associations between DTI metrics at one month and pain-related/psychological outcomes at six months within the mTBI group.
Identified group differences in the right sagittal stratum, left insula, and left superior longitudinal fasciculus.

Conclusions:

DTI metrics obtained one month after mTBI are sensitive to underlying brain microstructural changes.
These DTI metrics can predict the development of chronic pain and psychological difficulties six months post-injury.
Highlights the potential of DTI in understanding mTBI pathophysiology and long-term consequences.