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Silicone Rubber Catheters Modified by Poly(N-vinylpyrrolidone) Graft Promoted by Gamma Rays
Jesús Enrique López-Meza1, Víctor Hugo Pino-Ramos1, Guadalupe Gabriel Flores-Rojas1,2
1Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City 04510, Mexico.
Polymers
|March 13, 2025
Summary
Graft polymerization functionalized silicone rubber catheters with poly(N-vinylpyrrolidone) to enhance properties for potential medical applications. This modification improved the material
Area of Science:
- Materials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Polymeric matrix functionalization via graft polymerization introduces new surface properties.
- Surface modifications enhance hydrophilicity, chemical reactivity, and molecular interactions.
- Functionalized materials have broad applications, especially in medicine as drug delivery systems.
Purpose of the Study:
- To graft poly(N-vinylpyrrolidone) onto silicone rubber (SR) catheters using gamma radiation.
- To investigate the influence of absorbed dose and monomer concentration on graft degree.
- To characterize the functionalized SR matrix and evaluate its drug loading capacity.
Main Methods:
- Graft polymerization of N-vinylpyrrolidone onto silicone rubber catheters initiated by gamma radiation.
- Characterization using Thermogravimetric Analysis (TGA), wettability kinetics, ATR-FTIR, and Raman spectroscopy.
- Evaluation of drug loading capacity on the functionalized material.
Main Results:
- Successful incorporation of poly(N-vinylpyrrolidone) onto the SR catheter surface.
- Graft degree was dependent on absorbed dose and monomer concentration.
- Characterization confirmed successful functionalization and demonstrated potential for drug loading.
Conclusions:
- Gamma radiation-induced graft polymerization is an effective method for functionalizing SR catheters.
- The poly(N-vinylpyrrolidone) grafted SR matrix exhibits altered surface properties suitable for biomedical applications.
- The functionalized catheters show promise as drug delivery systems.
