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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
The Facile Synthesis of Exogenous Lewis-Base-Free Amidoalanes: A Structural Comparison
Jake Hemsworth1, Andrej Vinogradov2, William Lewis2
1Department of Chemistry, University of Manchester, Manchester M13 9PL, UK.
Abstract:
A simple one-pot reaction of LiAlH4, AlCl3, and a secondary amine HNR2 [R = Et, Pr, Bu, cyclo-C6H11, (CH2)4, and (CH2)5] in hydrocarbon solvents results in the formation of exogenous Lewis-base-free amidoalanes [H2Al(NR2)]n (n = 2 or 3) as crystalline solids (35-85% yield). In the solid state (seven X-ray structures), all the amidoalanes exist as dimers, with the exception of the pyrrolidine-derived alane which exists as a trimer. As solids, these amidoalanes exhibit significant kinetic stability towards oxygen/moisture allowing the brief (ca. 5 min.) handling of [H2Al(NPr2)]2 in air.
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