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Updated: May 22, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

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Anti-Epstein-Barr Virus Activities of Flavones and Flavonols with Effects on Virus-Related Cancers

Sherif T S Hassan1

  • 1Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Prague, Czech Republic.

Molecules (Basel, Switzerland)
|March 13, 2025
PubMed

Insights

Flavones and flavonols show therapeutic potential against Epstein-Barr virus (EBV) and associated cancers. These natural compounds may offer effective treatments with reduced drug resistance for EBV infections and malignancies.

Area of Science:

  • Virology
  • Oncology
  • Natural Product Chemistry

Background:

  • Epstein-Barr virus (EBV), a human gamma-herpesvirus, is implicated in numerous human cancers.
  • Current treatments like acyclovir for EBV infections have limited efficacy and face drug resistance challenges.
  • Novel therapeutic strategies are crucial for combating EBV-associated malignancies.

Purpose of the Study:

  • To review the therapeutic potential of flavones and flavonols against EBV and EBV-linked cancers.
  • To explore the molecular mechanisms of action for these natural compounds in viral and cancer pathways.
  • To identify future research directions for developing targeted EBV therapies.

Main Methods:

  • Literature review of existing research on flavones, flavonols, EBV, and associated cancers.
  • Analysis of molecular mechanisms targeting viral replication and tumor development.
  • Synthesis of current findings and identification of therapeutic targets.

Main Results:

  • Flavones and flavonols demonstrate promising antiviral and anticancer activities against EBV.
  • These compounds target key genes and proteins involved in the EBV life cycle and oncogenesis.
  • Evidence suggests a potential for overcoming existing drug resistance mechanisms.

Conclusions:

  • Flavones and flavonols represent a promising class of natural compounds for developing novel EBV therapies.
  • Targeting viral and host factors with these compounds could lead to effective treatments for EBV-associated cancers.
  • Further research is warranted to optimize their therapeutic application and clinical translation.
Keywords:
EBV life cycleEBV-associated cancersEpstein–Barr virusanticancer effectsantiviral propertiesflavonesflavonoidsflavonolshost–EBV interactionviral and cellular genesviral and cellular proteins

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