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Updated: May 22, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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HPF1 Regulates Pol β Efficiency in Nucleosomes via the Modulation of Total Poly(ADP-Ribose) Synthesis

Mikhail Kutuzov1, Dinara Sayfullina1, Ekaterina Belousova1

  • 1Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS, 630090 Novosibirsk, Russia.

International Journal of Molecular Sciences
|March 13, 2025
PubMed
Summary

HPF1 protein regulates DNA repair by modulating poly(ADP-ribosyl)ation, enhancing short-patch base excision DNA repair (BER) DNA synthesis in nucleosomes. This protein also positively influences long-patch BER efficiency.

Keywords:
BERDNA polymerase ?HPF1PARP1PARP2base excision DNA repairhistone PARylation factor 1nucleosomepoly(ADP-ribose)polymerase

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