Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

371
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
371
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

409
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
409
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

202
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
202
Liver Regeneration01:24

Liver Regeneration

3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

375
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
375
What is the Immune System?01:38

What is the Immune System?

109.9K
Overview
109.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

McKittrick-Wheelock Syndrome Caused by Giant Tubulovillous Adenomas With Malignant Transformation: A Case Report.

Case reports in gastrointestinal medicine·2026
Same author

From Molecules to Biomarkers: Nogo Proteins and Receptors in the Early Detection of Type 2 Diabetes Complications: A Systematic Review.

International journal of molecular sciences·2026
Same author

Hepatic Encephalopathy Severity and Mortality Risk Stratification in Alcohol-Related Acute-on-Chronic Liver Failure.

Diagnostics (Basel, Switzerland)·2026
Same author

Analysis of Prognostic Significance of CD47 Expression in Newly Diagnosed Large B Cell Lymphoma.

Life (Basel, Switzerland)·2026
Same author

Plasma expression of long non-coding RNA <i>GAS5</i> and its prognostic significance in newly diagnosed multiple myeloma.

Frontiers in oncology·2026
Same author

Redox Imbalance in the Cardiohepatic Syndrome: The Emerging Role of Oxidative Stress in Cirrhosis-Associated Cardiac Dysfunction.

Antioxidants (Basel, Switzerland)·2026

Related Experiment Video

Updated: May 22, 2025

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.1K

A Closer Look into Autoimmune Liver Diseases.

Branka Filipovic1,2, Marija Marjanovic-Haljilji1, Dragana Blagojevic1

  • 1Department of Gastroenterology, Clinical and Hospital Center "Dr Dragisa Misovic-Dedinje", Heroja Milana Tepica 1, 11020 Belgrade, Serbia.

International Journal of Molecular Sciences
|March 13, 2025
PubMed
Summary

This review explores autoimmune liver diseases, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. It details their complex molecular mechanisms and discusses current and future treatment options.

Keywords:
autoimmune liver diseasehepatitisprimary biliary cholangitisprimary sclerosing cholangitis

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

2.9K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.5K

Related Experiment Videos

Last Updated: May 22, 2025

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.1K
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

2.9K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.5K

Area of Science:

  • Hepatology
  • Immunology
  • Gastroenterology

Background:

  • Autoimmune liver diseases (ALD) are chronic inflammatory conditions affecting the liver.
  • Key types include autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC).
  • These conditions can present as overlapping syndromes with complex, not fully understood, pathogenesis.

Purpose of the Study:

  • To review the molecular mechanisms underlying autoimmune liver diseases.
  • To summarize existing therapeutic strategies for ALD.
  • To explore potential future treatments for these chronic liver conditions.

Main Methods:

  • Literature review of existing research on autoimmune liver diseases.
  • Analysis of molecular pathways involved in ALD pathogenesis.
  • Synthesis of information on current and emerging therapeutic modalities.

Main Results:

  • Detailed explanation of the complex molecular mechanisms driving ALD.
  • Overview of established treatments for AIH, PBC, and PSC.
  • Identification of promising therapeutic targets and strategies for future development.

Conclusions:

  • Understanding the molecular basis of ALD is crucial for effective treatment.
  • Current therapies offer management but often do not provide a cure.
  • Further research into novel therapeutic modalities holds promise for improving outcomes in autoimmune liver diseases.