Related Experiment Video

Updated: May 22, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K

Unravelling the Regulatory Roles of lncRNAs in Melanoma: From Mechanistic Insights to Target Selection

Beatrice Moras1, Claudia Sissi1

  • 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.

International Journal of Molecular Sciences
|March 13, 2025
PubMed

Insights

Long non-coding RNAs (lncRNAs) offer new therapeutic targets for melanoma, the deadliest skin cancer. Understanding lncRNA functions and locations can accelerate the development of novel melanoma treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Melanoma is an aggressive skin cancer with limited treatment options.
  • Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression.
  • lncRNAs' complex regulatory roles in cellular processes are not fully understood in melanoma.

Purpose of the Study:

  • To analyze recent findings on lncRNAs in melanoma.
  • To explore the functional mechanisms of lncRNAs in melanoma progression.
  • To highlight the impact of subcellular localization on lncRNA function in melanoma.

Main Methods:

  • Literature review of recent studies on lncRNAs and melanoma.
  • Analysis of lncRNA regulatory functions (chromatin remodeling, transcription, etc.).
  • Investigation of lncRNA subcellular localization and its functional implications.

Main Results:

  • lncRNAs play critical roles in regulating melanoma cell processes.
  • Diverse mechanisms of action for lncRNAs, including transcriptional and post-transcriptional regulation.
  • Subcellular localization of lncRNAs influences their function in melanoma.

Conclusions:

  • lncRNAs represent promising therapeutic targets for melanoma.
  • Understanding lncRNA networks can guide the development of novel melanoma therapies.
  • Further research into lncRNA mechanisms and localization is crucial for advancing melanoma treatment.
Keywords:
chromatin remodelinglncRNAmelanomatranscriptional regulationtranslational regulation

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.5K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.2K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K