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Related Concept Videos

Plasticizers01:31

Plasticizers

Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Superplasticizers01:30

Superplasticizers

Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...

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Intra-lymph Node Injection of Biodegradable Polymer Particles
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Development of a PLA Polymer-Based Liquid Filler for Next-Generation Aesthetics.

Ji Hyun Sung1, Na Jeong Park1, Jeong Eun Park1

  • 1Samyang Holdings Biopharmaceutical Group R&D Center, Seongnam 13488, Republic of Korea.

International Journal of Molecular Sciences
|March 13, 2025
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Summary

A novel biodegradable filler, DMSB01, rapidly reconstructs and disperses, effectively boosting collagen production to improve skin aging and wrinkles in animal models.

Keywords:
PLA fillerbiodegradable polymercollagen stimulatordermal fillerphagocytosisskin rejuvenation

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Regenerative Medicine

Background:

  • Skin aging, both natural and UV-induced, leads to collagen and elastin loss, causing soft tissue volume reduction.
  • Current biodegradable polymer fillers face limitations like slow reconstruction and particle clumping.
  • DMSB01, a poly d-l-lactic acid (PDLLA) filler with a methoxy polyethylene glycol (mPEG) initiator, was developed to address these issues.

Purpose of the Study:

  • To evaluate the in vitro reconstruction and dispersion properties of the DMSB01 filler.
  • To assess the efficacy of DMSB01 in promoting collagen expression and improving skin aging in a rat model.

Main Methods:

  • In vitro assessment of DMSB01 filler reconstruction and dispersion stability.
  • In vivo study using rat aging and photoaging models.
  • Analysis of macrophage polarization, growth factor expression (TGF-β), and collagen types I and III.
  • Histological evaluation using hematoxylin and eosin (H&E) staining for safety and biodegradability.

Main Results:

  • DMSB01 demonstrated rapid gelation (within 5 min at 37 °C) and excellent dispersion stability.
  • The filler induced M2 macrophages and Transforming Growth Factor beta (TGF-β) expression in vivo.
  • Significant increases in collagen types I and III were observed, leading to collagen recovery and wrinkle improvement.
  • H&E staining confirmed the safety and biodegradability of DMSB01.

Conclusions:

  • DMSB01 filler is effective in stimulating collagen production and ameliorating signs of skin aging.
  • Its rapid reconstruction and stable dispersion overcome limitations of existing fillers.
  • DMSB01 shows potential as an innovative cosmetic ingredient for skin rejuvenation.