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Diastolic Dysfunction Unveiling Cardiac Light-Chain Amyloidosis: A Case Report

Somesh Saha1, Ritwick Mondal2, Shramana Deb3

  • 1Department of Critical Care Medicine, Belle Vue Clinic, Kolkata, India.

Medical Research Archives
|March 13, 2025
PubMed

Insights

Cardiac light-chain amyloidosis significantly impacts survival, with deposition extent being key. Early diagnosis and treatment are crucial for halting progression and improving patient outcomes in this serious condition.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Nephrology

Background:

  • Cardiac light-chain amyloidosis is a critical, multi-systemic disease.
  • The extent of cardiac free light-chain deposition is the primary determinant of survival.

Purpose of the Study:

  • To highlight the importance of early diagnosis and prompt treatment for cardiac amyloidosis.
  • To present a case illustrating the diagnostic process and clinical presentation of cardiac amyloidosis.

Main Methods:

  • Case report of a 67-year-old male with relevant medical history.
  • Diagnostic workup included 12-lead electrocardiogram, 2D echocardiography, cardiac magnetic resonance imaging, nuclear imaging, and biopsy.

Main Results:

  • The patient presented with symptoms suggestive of cardiac compromise.
  • Diagnostic imaging and biopsy confirmed cardiac light-chain amyloidosis.
  • Key findings included left ventricular hypertrophy, restrictive filling, and pericardial effusion.

Conclusions:

  • Timely recognition and a high index of suspicion are essential for early diagnosis.
  • Prompt diagnosis allows for initiation of definitive therapy.
  • Effective treatment can halt disease progression and significantly improve prognosis.
Abstract

Keywords:
Heart failureLight chainamyloidosiscardiac amyloidosishypertrophy

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